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Cattle Drive Casserole

A hearty, layered casserole that combines seasoned ground beef, a tender biscuit base, a creamy sour cream layer, salsa pockets, and melted cheddar — perfect for weeknights or potlucks.
Print Recipe
Prep Time 20 minutes
Cook Time 40 minutes
Total Time 1 hour
Servings: 8 servings
Course: Dinner, Main Course
Cuisine: American, Comfort Food
Calories: 350
Ingredients Method Notes

Ingredients
  

For the Biscuit Base
  • 2.5 cups Biscuit Mix, like Bisquick
  • 1 cup Water
  • Cooking Spray, like Pam For greasing the casserole dish
For the Meat Filling
  • 1.5 pounds Lean Ground Beef Cooked until no longer pink
  • 1 medium Red Bell Pepper, seeded, chopped
  • 1 medium Yellow Onion, chopped
  • 1 ounce Taco Seasoning Mix
  • 1 teaspoon Garlic Powder
For the Creamy Layer
  • ½ cup Sour Cream
  • ½ cup Mayonnaise
  • 4 ounces Diced Green Chiles, drained
  • 1.5 cups Cheddar Cheese, Fiesta Blend, shredded, divided Reserve ¾ cup for the creamy layer and the rest for topping
For Assembling
  • ½ cup Salsa, mild To dot over the sour cream layer

Method
 

Preparation
  1. Preheat the oven to 350℉.
  2. In a skillet over medium-high heat, add the ground beef and cook until browned, stirring occasionally. Drain off excess fat.
  3. In a mixing bowl, combine biscuit mix and water until well mixed. Press the dough into a greased casserole dish and bake for 5-8 minutes until set and lightly golden.
  4. Add chopped onions and red bell pepper to the cooked ground beef. Cook for about 4 minutes, then add taco seasoning and mix well. Remove from heat.
Assembling
  1. Spread the ground beef mixture evenly over the baked biscuit layer.
  2. In a bowl, combine sour cream, mayonnaise, green chiles, ¾ cup shredded cheese, and garlic powder. Mix until smooth and spread over the beef layer.
  3. Dot small spoonfuls of salsa over the sour cream layer and sprinkle the remaining cheese on top.
Baking
  1. Bake the assembled casserole in the oven uncovered for 30 minutes or until hot and bubbly.

Notes

Let the casserole rest 5–10 minutes after baking for cleaner slices. Serve with garnishes like chopped cilantro or green onions.